Juxtacrine Activation of EGFR by Membrane-anchored HB-EGF Protects Epithelial Cells from Anoikis While Maintaining an Epithelial Phenotype
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چکیده
Juxtacrine Activation of EGFR by Membrane-anchored HB-EGF Protects Epithelial Cells from Anoikis While Maintaining an Epithelial Phenotype Amar B. Singh, Keisuke Sugimoto and Raymond C. Harris Department of Medicine, Vanderbilt University, Nashville, Tennessee-37232 Running Title: HB-EGF prevents Anoikis in MDCK cells. Address Correspondence to: Raymond C. Harris, M.D., C-3121 Medical Center North, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-4794, Office: (615) 343-0030, Fax: (615) 343-7156, E-mail: [email protected]
منابع مشابه
Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance.
Heparin-binding (HB)-EGF, a ligand for EGF receptors, is synthesized as a membrane-anchored precursor that is potentially capable of juxtacrine activation of EGF receptors. However, the physiological importance of such juxtacrine signaling remains poorly described, due to frequent inability to distinguish effects mediated by membrane-anchored HB-EGF vs. mature "secreted HB-EGF." In our studies,...
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All ligands of the epidermal growth factor (EGF) receptor (EGFR) are synthesized as membrane-anchored precursors. Previous work has suggested that some ligands, such as EGF, must be proteolytically released to be active, whereas others, such as heparin-binding EGF-like growth factor (HB-EGF) can function while still anchored to the membrane (i.e., juxtacrine signaling). To explore the structura...
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